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Lumières dans l'obscurité

SANDRINE BOULET

PROFESIONNAL WEBSITE

WHO I AM?

PhD in Biostatistics

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INSERM and INRIA, team HeKA

[Version française ici]

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CV

PROFESIONAL EXPERIENCES AND INTERNSHIPS

  • Since September 2020: Post-doctoral position in Biostatistics about the development of new methods for pre-clinical extrapolation for the European project "FAIR", with Sarah Zohar - Nationale Institute of Health and Medical Research (INSERM) and National institute for research in digital science and technology (INRIA), team HeKA  - PariSanté Campus in Paris, France.

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  • Since September 2020: Teaching in Mathematics and applied Mathematics - Social sciences track and sciences track in Versailles / Saint-Quentin-en-Yvelines University (UVSQ); Faculty of Pharmacy of Paris University, France.

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  • September 2019 - August 2020: Post-doctoral project in Statistics using neural networks to build realistic simulation schemes for causal analysis, with Antoine Chambaz, Laboratory of Applied Mathematics of Paris Descartes University (MAP5), National Centre for Scientific Research (CNRS) UMR 8145.

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  • September 2018 - August 2020: Research and teaching assistant (ATER) in Mathematics and applied Mathematics - CNRS UMR 8100 Team "Probability and Statistics" - Versailles Mathematics Laboratory (LMV), sciences track in UVSQ, Versailles, France. 

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  • September 2016 - August 2018: Teaching in Biostatistics, Life sciences track in Paris-Diderot University, Paris, France.

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  • October 2015 - September 2019:  PhD in Biostatistics « Development of Bayesian variable selection methods to integrate expert information » , with Sarah Zohar and Anne-Sophie Jannot - Paris-Descartes University – INSERM UMRS 1138 Team 22 "Information Sciences to support personalized medicine" - Cordeliers Research Center (CRC) and Georges Pompidou European Hospital (HEGP) in Paris, France.

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  • April - Septembre 2015: Internship in Biostatistics « Dose-finding designs for acute and cumulative toxicities » ,  with Sarah Zohar - INSERM UMRS1138 Team 22 – CRC in Paris, France.

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  • June - August 2014: Internship in Statistics « Comparison of the survival of patients with Steinert disease compared to the French population », with Guillaume Bassez and Sandrine Katsahian - Reference center for neuromuscular diseases at Henri Mondor Hospital in Créteil, France.

EDUCATION

  • 2014 - 2015: Master degree in Mathematical Research & Applications, Mathematical Statistics speciality, Rennes 1 University, France.

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  • 2012 - 2015: Engineering degree in Statistics, Biostatistics speciality, ENSAI (National School of Statistics and Information Analysis), Bruz, France.

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  • 2009 - 2012: Preparatory classes : two-year undergraduate intensive course in mathematics and physics, Lycée Marceau, Chartres, France.

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  • 2009: Scientific Baccalaureate, with honours, mathematics speciality, Lycée Louis Bascan, Rambouillet, France.

RESEARCH TOPICS

Bayesian approach; variables selection methods; elicited expert data; dose-finding; synthetic data generation; neural networks (GAN and VAE).

RESEARCH PROJECT EVALUATION

  • 2023: French Center for 3R (FC3R), Evaluation of projects of numerical approaches in biology for the call for projects "Replacement : alternatives to animal models and animal products in scientific research".

RESEARCH PAPERS REVIEWING

Biostatistics, Statistics in Biopharmaceutical Research, Pharmaceutical Statistics..

IT TOOLS

  • R, PFIM, MONOLIX, STAN, JAGS, WinBUGS/OpenBUGS;

  • LaTeX, Word, Excel, Powerpoint;

  • Notions in Linux et Python (Keras);

  • SNDS data training.

FOREIGN LANGUAGES

  • French: mother tongue;

  • English: B2 level (CEFR) (TOEIC obtained in January 2014);

  • Spanish: B2 level (CEFR).

Formules mathématiques

SCIENTIFIC PRODUCTIONS

PUBLICATIONS

  • Boulet S., Comets E., Guillon A., Aulin L.B.S., Michelet R., Kloft C., Zohar S., Ursino M., Straightforward Phase I Dose-Finding Design for Healthy Volunteers Accounting for Surrogate Activity Biomarkers, Statistics in Biopharmaceutical Research (2024), 1–13. https://doi.org/10.1080/19466315.2024.2416410

  • Boulet S., Ursino M., Michelet R., Aulin L.B.S., Kloft C., Comets E., Zohar S.,  Bayesian framework for multi-source data integration-Application to human extrapolation from preclinical studies, Statistical Methods in Medical Research (2024); 33(4): 574-588. https://doi.org/10.1177/09622802241231493​

  • Michelet R., Ursino M., Boulet S., Franck S., Casilag F., Baldry M., Rolff J., van Dyk M., Wicha S.G., Sirard J.-C., Comets E., Zohar S., Kloft C., The Use of Translational Modelling and Simulation to Develop Immunomodulatory Therapy as an Adjunct to Antibiotic Treatment in the Context of Pneumonia, Pharmaceutics (2021); 13(5):601. https://doi.org/10.3390/pharmaceutics13050601

  • Boulet S., Ursino M., Thall P., Landi B., Lepère C., Pernot S., Burgun A., Taieb J., Zaanan A., Zohar S., Jannot A.-S., Integration of elicited expert information via a power prior in Bayesian variable selection: application to colon cancer data, Statistical Methods in Medical Research (2020); 29(2):541-567. https://doi.org/10.1177/0962280219841082

  • Boulet S., Ursino M., Thall P., Jannot A.-S., Zohar S., Bayesian variable selection based on clinical relevance weights in small sample studies – Application to colon cancer, Statistics in Medicine (2019) ; 1-20. https://doi.org/10.1002/sim.8107 ​

  • Jacob L., Uvarova M., Boulet S., Begaj I., Chevret S., Evaluation of a multi-arm multi-stage Bayesian design for phase II drug selection trials – an example in hematooncology, BMC Medical Research Methodology (2016) ; 16 :67. https://doi.org/10.1186/s12874-016-0166-7

Salle de classe vide

TEACHING

 

Paris-Diderot University - Life Sciences track (2016-2018)

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  • Tutorials of Probability and Biostatistics for second year student - Persons in charge: Bruno Toupance, Olivier Taboureau and Delphine Flatters; Number of hours: 18h x 2 years.

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  • Lectures / tutorials / practical work of Introduction to Biostatistics for PhD students - Persons in charge: Anne Badel and Anne-Claude Camproux; Number of hours: 24h x 2 years.

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  • Tutorials / practical work of Statistics applied to biology for second year students - Persons in charge: Sylvie Escolano and Leslie Regad; Number of hours: 18h x 2 years.

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Versailles / Saint-Quentin-en-Yvelines University - Sciences track (2018-2024)

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  • Lectures / Tutorials of General Mathematics (LSMA100B) for first year student in Bio-Informatic (BI) and Chemistry-Biology (CB) - Person in charge: Pierre Gabriel; Number of hours: (54h+60h) x 2 years + 6h + 36h x 2 years

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  • Tutorials of Probability and statistics for biology (LSMA203N) for first year student in CB and Double-License CB (DLCB)  - Person in charge: Oleksiy Khorunzhiy; Number of hours: 36h x (2 groups x 2 years + 1 group x 1 year)

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  • Tutorials of General Mathematics 2 (LSMA202N) for first year student in Mathematics and Informatics Applied to Human and Social Sciences (MIASHS) - Person in charge: Maëlle Nodet; Number of hours: 6h

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  • Tutorials of Statistics 2 (LEECO322) for second year student in Social Sciences - Person in charge: Bernhard Elsner; Number of hours: 24h

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Paris Cité University - Faculty of Pharmacy (2021-2023)

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  • Tutorials / practical work of Data Science for second year student in Interdisciplinary Sciences Applied to Health (SIAS) (SA13E400 UE4) - Person in charge : Moreno Ursino; Number of hours: 14h + 2h

CONTACT

PariSanté Campus
3ème étage
10 rue d'Oradour-sur-Glane
75015 Paris, FRANCE

sandrine.boulet@inria.fr

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